Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472621 | 0.91 | MAPT (0.51) | MAPTMEN1KMT2AHSD17B10CYP1A2 | |
| SCHEMBL7471263 | 0.90 | GABRA1 (0.51) | MAPTMEN1KMT2AHSD17B10CYP1A2 | |
| SCHEMBL7461988 | 0.88 | MAOB (0.43) | MAPTMEN1KMT2AHSD17B10CYP1A2 | |
| SCHEMBL7462845 | 0.82 | ALOX5 (0.49) | MAPTMEN1KMT2AHSD17B10CYP1A2 | |
| SCHEMBL7465568 | 0.81 | EDNRB (0.47) | MAPTMEN1KMT2AHSD17B10CYP1A2 | |
| SCHEMBL7465999 | 0.80 | NR4A2 (0.42) | MAPTMEN1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL7466748 | 0.79 | KDM4E (0.49) | MAPTHSD17B10CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL7458027 | 0.77 | S1PR1 (0.46) | MAPTHSD17B10HPGDKDM4ELMNA | |
| SCHEMBL8387936 | 0.76 | MAPT (0.47) | MAPTTSHRHPGDSMN1; SMN2LMNA | |
| SCHEMBL7466286 | 0.75 | MAOA (0.49) | MAPTMEN1KMT2AHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021181-A4 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORP (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1021181-A1 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997035572-A1 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-02 | — | — | WO | disclosed |