Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SAT1 | P21673 | 1/20 | 0.41 |
| ▸ | ADH1B | P00325 | 1/20 | 0.39 |
| ▸ | ADH1C | P00326 | 1/20 | 0.39 |
| ▸ | ADH1A | P07327 | 1/20 | 0.39 |
| ▸ | ADH4 | P08319 | 1/20 | 0.39 |
| ▸ | ADH7 | P40394 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038182 | 1.00 | KMT2A (0.50) | KMT2ASAT1ADH1BADH1CADH1A | |
| SCHEMBL13936062 | 0.81 | SAT1 (0.41) | KMT2ASAT1ADH1BADH1CADH1A | |
| SCHEMBL8047473 | 0.80 | PKM (0.47) | SAT1ADH1BADH1CADH1AADH4 | |
| SCHEMBL9043042 | 0.80 | ADH1C (0.42) | KMT2ASAT1ADH1BADH1CADH1A | |
| SCHEMBL24296754 | 0.77 | SAT1 (0.48) | SAT1ADH1BADH1CADH1AADH4 | |
| SCHEMBL8393600 | 0.77 | SAT1 (0.48) | SAT1ADH1BADH1CADH1AADH4 | |
| SCHEMBL11922715 | 0.77 | SAT1 (0.48) | SAT1ADH1BADH1CADH1AADH4 | |
| SCHEMBL13355719 | 0.77 | KMT2A (0.39) | KMT2APOLBTSHRLMNACYP1A2 | |
| SCHEMBL11594234 | 0.76 | ADH1B (0.54) | KMT2ASAT1ADH1BADH1CADH1A | |
| SCHEMBL5626798 | 0.74 | SAT1 (0.50) | SAT1ADH1BADH1CADH1AADH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693070-B1 | PYRIDO[2,3-b](1,4)BENZODIAZEPINONES AS M2 RECEPTOR LIGAND FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | PHARMACEUTICAL DISCOVERY CORP (US) | 2002-07-24 | — | — | EP | disclosed |
| EP-1120416-A1 | Pyrido[2.3-b][1,4]benzodiazepinones as M2 receptor ligand for the treatment of neurological disorders | PHARMACEUTICAL DISCOVERY CORPORATION (US) | 2001-08-01 | — | — | EP | disclosed |
| US-5712269-A | COGNITION ACTIVATORS | PHARMACEUTICAL DISCOVERY CORPORATION (US) | 1998-01-27 | — | — | US | disclosed |
| EP-0693070-A1 | PYRIDO 2,3-b] 1,4]BENZODIAZEPINONES AS M 2? RECEPTOR LIGAND FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | PHARMACEUTICAL DISCOVERY CORPORATION (US) | 1996-01-24 | — | — | EP | disclosed |
| WO-1994022861-A1 | PYRIDO[2,3-b][1,4]BENZODIAZEPINONES AS M2 RECEPTOR LIGAND FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | PHARMACEUTICAL DISCOVERY CORPORATION (US) | 1994-10-13 | — | — | WO | disclosed |