Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | ESRRG | P62508 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
| ▸ | ESRRB | O95718 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL747648 | 0.99 | PARP1 (0.36) | PARP1SLC6A9KCNH2PSEN1PSEN2 | |
| SCHEMBL747122 | 0.94 | TP53 (0.33) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL746591 | 0.94 | PARP1 (0.33) | PARP1KCNH2PSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL748492 | 0.94 | TP53 (0.33) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL745512 | 0.93 | OPRM1 (0.34) | PARP1PSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL747110 | 0.92 | OPRM1 (0.34) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL747155 | 0.92 | TP53 (0.38) | PARP1PSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL748268 | 0.91 | TP53 (0.38) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL745516 | 0.89 | PARP1 (0.35) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL746554 | 0.88 | TP53 (0.34) | TP53MAPTNR1H4ESRRGOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |