Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7462222 | 1.00 | ACHE (0.41) | ACHETSHRSLC6A4OPRM1OPRL1 | |
| SCHEMBL7460954 | 1.00 | ACHE (0.41) | ACHETSHRSLC6A4OPRM1OPRL1 | |
| SCHEMBL7460948 | 1.00 | ACHE (0.41) | ACHETSHRSLC6A4OPRM1OPRL1 | |
| SCHEMBL7467958 | 1.00 | ACHE (0.41) | ACHETSHRSLC6A4OPRM1OPRL1 | |
| SCHEMBL7411786 | 0.76 | SLC6A4 (0.47) | ACHETSHRSLC6A4HTR2AHTR2C | |
| SCHEMBL7411787 | 0.76 | SLC6A4 (0.47) | ACHETSHRSLC6A4HTR2AHTR2C | |
| SCHEMBL7413066 | 0.76 | SLC6A4 (0.47) | ACHETSHRSLC6A4HTR2AHTR2C | |
| SCHEMBL7420516 | 0.76 | SLC6A4 (0.47) | ACHETSHRSLC6A4HTR2AHTR2C | |
| SCHEMBL9465607 | 0.75 | SIGMAR1 (0.42) | OPRM1OPRL1SIGMAR1GAAMEN1 | |
| SCHEMBL7414031 | 0.75 | SIGMAR1 (0.42) | OPRM1OPRL1SIGMAR1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276026-A | Tetrahydroethanonaphthaleneamine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1994-01-04 | — | — | US | disclosed |
| US-5202486-A | Tetrahydroethanonaphthaleneamine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |