Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FABP7 | O15540 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9465607 | 1.00 | SIGMAR1 (0.42) | SIGMAR1CHRM5CHRM1CHRM3CCR5 | |
| SCHEMBL7414005 | 0.79 | SIGMAR1 (0.46) | SIGMAR1CHRM5CHRM1CHRM3OPRM1 | |
| SCHEMBL7414002 | 0.79 | SIGMAR1 (0.46) | SIGMAR1CHRM5CHRM1CHRM3OPRM1 | |
| SCHEMBL9466894 | 0.78 | SIGMAR1 (0.45) | SIGMAR1CHRM5CHRM1CHRM3CCR5 | |
| SCHEMBL7460954 | 0.75 | ACHE (0.41) | SIGMAR1OPRM1OPRL1MEN1KMT2A | |
| SCHEMBL7471572 | 0.75 | ACHE (0.41) | SIGMAR1OPRM1OPRL1MEN1KMT2A | |
| SCHEMBL7467958 | 0.75 | ACHE (0.41) | SIGMAR1OPRM1OPRL1MEN1KMT2A | |
| SCHEMBL7412849 | 0.70 | SIGMAR1 (0.49) | SIGMAR1CHRM5CHRM1CHRM3CCR5 | |
| SCHEMBL7412853 | 0.70 | SIGMAR1 (0.49) | SIGMAR1CHRM5CHRM1CHRM3CCR5 | |
| SCHEMBL19390631 | 0.68 | SIGMAR1 (0.60) | SIGMAR1CHRM5CHRM1CHRM3CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276026-A | Tetrahydroethanonaphthaleneamine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1994-01-04 | — | — | US | disclosed |
| US-5202486-A | Tetrahydroethanonaphthaleneamine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |