SCHEMBL7471585

SCHEMBL7471585

CN(CCOc1cccc2c1CC(=O)N2)Cc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.61
DRD4 P21917 1/20 0.61
DRD3 P35462 1/20 0.61
HTR1D P28221 1/20 0.54
HTR1B P28222 1/20 0.54
LMNA P02545 1/20 0.46
HTR6 P50406 1/20 0.45
TSHR P16473 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
ATM Q13315 1/20 0.42
ACHE P22303 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7470775 0.82 ATM (0.49) HTR1DHTR1BATM
SCHEMBL9385737 0.80 DRD2 (0.49) DRD2DRD4DRD3LMNAACHE
SCHEMBL7474135 0.79 DRD2 (0.53) DRD2DRD4DRD3LMNAHTR6
SCHEMBL5638400 0.79 DRD2 (0.67) DRD2DRD4DRD3L3MBTL1
SCHEMBL9389090 0.77 KCNH2 (0.56) DRD2DRD4DRD3LMNA
SCHEMBL7448312 0.77 DRD2 (0.45) DRD2DRD4DRD3LMNA
SCHEMBL7478147 0.76 DRD2 (1.00) DRD2DRD4DRD3HTR6
Hydrochloric Acid SCHEMBL7443067 0.76 DRD2 (0.44) DRD2DRD4DRD3LMNAACHE
SCHEMBL7470425 0.76 DRD2 (0.44) DRD2DRD4DRD3LMNATSHR
SCHEMBL9389030 0.75 KCNH2 (0.58) DRD2DRD4DRD3LMNAACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923551-B1 4-AMINOETHOXY INDOLONE DERIVATIVES AMERICAN HOME PROD (US) 2002-06-05 EP claimed
EP-0923551-A1 4-AMINOETHOXY INDOLONE DERIVATIVES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-06-23 EP claimed
WO-1998008819-A1 4-AMINOETHOXY INDOLONE DERIVATIVES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-03-05 WO claimed
EP-0923551-B1 4-AMINOETHOXY INDOLONE DERIVATIVES AMERICAN HOME PROD (US) 2002-06-05 EP disclosed