Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471585 | 0.82 | DRD2 (0.61) | ATMHTR1DHTR1B | |
| SCHEMBL7475432 | 0.77 | DRD2 (0.68) | — | |
| SCHEMBL8307936 | 0.76 | PDE5A (0.39) | — | |
| SCHEMBL8310167 | 0.74 | PDE5A (0.39) | — | |
| SCHEMBL7470200 | 0.74 | POLB (0.45) | MAPTMAPK1 | |
| SCHEMBL7472643 | 0.72 | DRD2 (0.60) | — | |
| SCHEMBL8392215 | 0.72 | HTR1D (0.52) | ATMKDM4EMAPTMAPK1HTR1D | |
| SCHEMBL11088266 | 0.70 | AHR (0.49) | — | |
| Hydrochloric Acid SCHEMBL8743657 | 0.70 | ATM (0.50) | ATMKDM4EMAPTMAPK1HTR1D | |
| SCHEMBL7475073 | 0.70 | POLB (0.56) | KDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923551-B1 | 4-AMINOETHOXY INDOLONE DERIVATIVES | AMERICAN HOME PROD (US) | 2002-06-05 | — | — | EP | claimed |
| EP-0923551-A1 | 4-AMINOETHOXY INDOLONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-23 | — | — | EP | claimed |
| WO-1998008819-A1 | 4-AMINOETHOXY INDOLONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-05 | — | — | WO | claimed |
| EP-0923551-B1 | 4-AMINOETHOXY INDOLONE DERIVATIVES | AMERICAN HOME PROD (US) | 2002-06-05 | — | — | EP | disclosed |