Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | CTSC | P53634 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 2/20 | 0.30 |
| ▸ | HRH1 | P35367 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6922149 | 0.87 | MEN1 (0.35) | MEN1CYP2D6KMT2AHRH2HRH1 | |
| SCHEMBL743847 | 0.79 | ELANE (0.42) | CTSCHRH2HRH1 | |
| SCHEMBL7289268 | 0.76 | HTR2C (0.38) | CTSKCTSCCYP2D6HRH2HRH1 | |
| SCHEMBL28289372 | 0.72 | CTSC (0.38) | CTSC | |
| SCHEMBL9867712 | 0.70 | ALDH1A1 (0.42) | CNR2MEN1KMT2A | |
| SCHEMBL11716695 | 0.68 | MEN1 (0.62) | MEN1CYP2D6KMT2A | |
| SCHEMBL2184831 | 0.68 | CYP1A2 (0.50) | MEN1CYP2D6KMT2A | |
| SCHEMBL232050 | 0.68 | NPC1 (0.47) | MEN1CYP2D6KMT2A | |
| SCHEMBL1512969 | 0.68 | CYP1A2 (0.50) | MEN1CYP2D6KMT2A | |
| SCHEMBL1512967 | 0.68 | CYP1A2 (0.50) | MEN1CYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431357-A2 | 3-Aminopyrrolidine Derivatives as Modulators of Chemokine Receptors | Incyte Corporation (US) | 2012-03-21 | — | — | EP | claimed |