Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783295 | 0.80 | GRIN1 (0.54) | DRD2DRD3DRD4GRIN2BGRIN1 | |
| SCHEMBL3311831 | 0.80 | MTNR1A (0.64) | GRIN2BGRIN1MAPK1MTNR1AMTNR1B | |
| SCHEMBL8783223 | 0.80 | GRIN2B (0.50) | DRD2DRD3DRD4GRIN2BGRIN1 | |
| SCHEMBL9449692 | 0.80 | GRIN2B (0.50) | DRD2DRD3GRIN2BGRIN1MAOA | |
| SCHEMBL14207337 | 0.79 | GRIN2B (0.51) | DRD2DRD3GRIN2BGRIN1MAOA | |
| SCHEMBL12891737 | 0.77 | DRD2 (0.44) | DRD2DRD3GRIN2BGRIN1CYP2D6 | |
| SCHEMBL30666578 | 0.77 | DRD2 (0.44) | DRD2DRD3GRIN2BGRIN1CYP2D6 | |
| SCHEMBL12891739 | 0.77 | DRD2 (0.44) | DRD2DRD3GRIN2BGRIN1CYP2D6 | |
| SCHEMBL10016895 | 0.77 | DRD2 (0.44) | DRD2DRD3GRIN2BGRIN1CYP2D6 | |
| SCHEMBL8783373 | 0.77 | GAA (0.50) | DRD2DRD3GRIN2BGRIN1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395244-B1 | Pyridine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1997-02-19 | — | — | EP | claimed |
| EP-0395244-A1 | Pyridine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1990-10-31 | — | — | EP | claimed |
| EP-0689534-B1 | AMIDE DERIVATIVES AS 5-HT 1A? LIGANDS | WYETH JOHN & BROTHER LTD (GB) | 2002-10-02 | — | — | EP | disclosed |
| EP-0687257-B1 | 4-AMINO-2-(HETERO)ARYL-BUTANAMIDES USEFUL AS 5-HT1A-ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1997-06-18 | — | — | EP | disclosed |
| US-5629323-A | Amide derivatives as 5-HT1A ligands | JOHN WYETH & BROTHER, LTD. (GB) | 1997-05-13 | — | — | US | disclosed |
| US-5610295-A | 4-amino-2-(hetero)aryl-butanamides useful as 5-HT1A -antagonists | JOHN WYETH & BROTHER, LTD. (GB) | 1997-03-11 | — | — | US | disclosed |
| EP-0395244-B1 | Pyridine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| EP-0689534-A1 | AMIDE DERIVATIVES AS 5-HT 1A? LIGANDS | JOHN WYETH & BROTHER LIMITED (GB) | 1996-01-03 | — | — | EP | disclosed |
| EP-0687257-A1 | 4-AMINO-2-(HETERO)ARYL-BUTANAMIDES USEFUL AS 5-HT1A-ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1995-12-20 | — | — | EP | disclosed |
| WO-1994021611-A1 | AMIDE DERIVATIVES AS 5-HT1A LIGANDS | JOHN WYETH & BROTHER LIMITED (GB) | 1994-09-29 | — | — | WO | disclosed |
| WO-1994020481-A1 | 4-AMINO-2-(HETERO)ARYL-BUTANAMIDES USEFUL AS 5-HT1A-ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |
| US-5194439-A | 5-HT Agonists or Antagonists, Nervous System Disorders, Hypotensive Agents | JOHN WYETH & BROTHER LIMITED (GB) | 1993-03-16 | — | — | US | disclosed |
| US-5075303-A | Central nervous system disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1991-12-24 | — | — | US | disclosed |
| EP-0395244-A1 | Pyridine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1990-10-31 | — | — | EP | disclosed |