Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 9/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.50 |
| ▸ | GBA1 | P04062 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472586 | 0.80 | DRD2 (0.48) | GRIN2BGRIN1MAPK1MAOAMAOB | |
| SCHEMBL30834531 | 0.79 | GBA1 (0.35) | GRIN2BGRIN1GBA1HDAC8HDAC6 | |
| SCHEMBL4043115 | 0.79 | GRIN2B (0.57) | GRIN2BGBA1MAOAMAOB | |
| SCHEMBL8783707 | 0.78 | GRIN2B (0.67) | GRIN2BGRIN1HDAC8HDAC6DRD2 | |
| Hydrochloric Acid SCHEMBL4053518 | 0.77 | GRIN2B (0.56) | GRIN2BGBA1MAOAMAOB | |
| SCHEMBL8783373 | 0.76 | GAA (0.50) | GRIN2BGRIN1MAPK1MAOAMAOB | |
| SCHEMBL8783887 | 0.76 | GRIN2B (0.71) | GRIN2BGRIN1 | |
| SCHEMBL8783223 | 0.76 | GRIN2B (0.50) | GRIN2BGRIN1HDAC8HDAC6MAPK1 | |
| SCHEMBL12895145 | 0.75 | GRIN1 (0.39) | GRIN2BGRIN1HDAC8HDAC6MAPK1 | |
| SCHEMBL12891737 | 0.74 | DRD2 (0.44) | GRIN2BGRIN1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395244-A1 | Pyridine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1990-10-31 | — | — | EP | claimed |
| US-5194439-A | 5-HT Agonists or Antagonists, Nervous System Disorders, Hypotensive Agents | JOHN WYETH & BROTHER LIMITED (GB) | 1993-03-16 | — | — | US | disclosed |
| US-5075303-A | Central nervous system disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1991-12-24 | — | — | US | disclosed |
| EP-0395244-A1 | Pyridine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1990-10-31 | — | — | EP | disclosed |