Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | EEF2K | O00418 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9247576 | 0.85 | PKM (0.46) | LMNAJAK2MEN1KMT2ACDK2 | |
| SCHEMBL9352767 | 0.81 | CA1 (0.46) | MAPTTP53MEN1KMT2AIDO1 | |
| SCHEMBL9352738 | 0.81 | LMNA (0.47) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL5227239 | 0.75 | GAA (0.50) | MEN1KMT2AALDH1A1 | |
| SCHEMBL18856402 | 0.74 | JAK2 (0.76) | MAPTJAK2MEN1KMT2A | |
| SCHEMBL9865806 | 0.70 | SLC40A1 (0.38) | LMNAKMT2AIDH1ALDH1A1 | |
| SCHEMBL27275299 | 0.70 | LMNA (0.49) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL2034092 | 0.69 | LMNA (0.52) | LMNAMAPTIDH1IDO1RAB9A | |
| SCHEMBL8313948 | 0.69 | GAA (0.38) | KMT2A | |
| SCHEMBL9156934 | 0.69 | LMNA (0.40) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724586-B1 | PROCESS FOR PREPARING N-(2,6-DICHLORO-3-METHYLPHENYL)-5-7-DIHALO[1,2,4]TRIAZOLO[1,5A]PYRIMIDINE-2-SULFONAMIDE BY CYCLIZATION AND HALO-DEHYDROXYLATION | DOW AGROSCIENCES LLC (US) | 2002-01-23 | — | — | EP | disclosed |
| EP-0724586-A1 | PROCESS FOR PREPARING N-(2,6-DICHLORO-3-METHYLPHENYL)-5-7-DIHALO 1,2,4]TRIAZOLO 1,5A]PYRIMIDINE-2-SULFONAMIDE BY CYCLIZATION AND HALO-DEHYDROXYLATION | DOWELANCO (US) | 1996-08-07 | — | — | EP | disclosed |
| EP-0444747-B1 | Preparation of 5,7-dihydroxy-1,2,4-triazolo(1,5-a)-pyrimidine-2-sulfonanilides | DOWELANCO (US) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995011246-A1 | PROCESS FOR PREPARING N-(2,6-DICHLORO-3-METHYLPHENYL)-5-7-DIHALO[1,2,4]TRIAZOLO[1,5A]PYRIMIDINE-2-SULFONAMIDE BY CYCLIZATION AND HALO-DEHYDROXYLATION | DOWELANCO (US) | 1995-04-27 | — | — | WO | disclosed |
| EP-0444747-A2 | Preparation of 5,7-dihydroxy-1,2,4-triazolo(1,5-a)-pyrimidine-2-sulfonanilides | DOWELANCO (US) | 1991-09-04 | — | — | EP | disclosed |
| US-5006656-A | Preparation of 5,7-dihydroxy-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonanilides | DOWELANCO (US) | 1991-04-09 | — | — | US | disclosed |