Hydroxyamine

SCHEMBL7472827

COc1ccc(S(=O)(=O)N(C)c2c(C(=O)O)cnc3ccc(C(C)c4ccccc4)cc23)cc1.NO

nearest known ligand 0.47

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	MMP1	P03956	9/20	0.47

▸	MMP9	P14780	9/20	0.47

▸	MMP13	P45452	9/20	0.47

▸	ADAM17	P78536	5/20	0.47

▸	C1R	P00736	1/20	0.43

▸	KEAP1	Q14145	5/20	0.43

▸	NFE2L2	Q16236	4/20	0.43

▸	PDE4B	Q07343	3/20	0.42

▸	TP53	P04637	1/20	0.41

▸	TAS2R14	Q9NYV8	1/20	0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7010429	0.90	MMP1 (0.60)	MMP1MMP9MMP13ADAM17
Hydroxyamine SCHEMBL7472830	0.83	MMP1 (0.54)	MMP1MMP9MMP13ADAM17C1R
SCHEMBL7355097	0.81	MMP1 (0.56)	MMP1MMP9MMP13ADAM17C1R
SCHEMBL6293228	0.81	MMP1 (0.49)	MMP1MMP9MMP13ADAM17C1R
Hydroxyamine SCHEMBL7420150	0.75	MMP1 (0.79)	MMP1MMP9MMP13ADAM17KEAP1
SCHEMBL7472837	0.75	MMP1 (0.53)	MMP1MMP9MMP13ADAM17KEAP1
SCHEMBL7010431	0.73	MMP1 (0.68)	MMP1MMP9MMP13ADAM17
SCHEMBL6289972	0.73	MMP1 (0.81)	MMP1MMP9MMP13ADAM17KEAP1
SCHEMBL6289453	0.72	MAPT (0.51)	MMP1MMP9MMP13ADAM17KEAP1
SCHEMBL6290010	0.71	MMP1 (0.85)	MMP1MMP9MMP13ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-1998016514-A1	ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS	AMERICAN CYANAMID COMPANY (US)	1998-04-23	—	—	WO	disclosed