Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 9/20 | 0.53 |
| ▸ | MMP13 | P45452 | 9/20 | 0.53 |
| ▸ | MMP9 | P14780 | 8/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamine SCHEMBL7472830 | 0.91 | MMP1 (0.54) | MMP1MMP13MMP9ADAM17KEAP1 | |
| SCHEMBL7355097 | 0.91 | MMP1 (0.56) | MMP1MMP13MMP9ADAM17KEAP1 | |
| SCHEMBL7010431 | 0.88 | MMP1 (0.68) | MMP1MMP13MMP9ADAM17 | |
| SCHEMBL7006362 | 0.81 | MMP1 (0.53) | MMP1MMP13MMP9ADAM17KEAP1 | |
| SCHEMBL7418158 | 0.78 | MMP13 (0.80) | MMP1MMP13MMP9ADAM17 | |
| SCHEMBL6289453 | 0.76 | MAPT (0.51) | MMP1MMP13MMP9ADAM17KEAP1 | |
| SCHEMBL7420153 | 0.75 | MMP1 (0.77) | MMP1MMP13MMP9ADAM17KEAP1 | |
| SCHEMBL6293228 | 0.75 | MMP1 (0.49) | MMP1MMP13MMP9ADAM17KEAP1 | |
| Hydroxyamine SCHEMBL7472827 | 0.75 | MMP1 (0.47) | MMP1MMP13MMP9ADAM17KEAP1 | |
| SCHEMBL7010429 | 0.72 | MMP1 (0.60) | MMP1MMP13MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998016514-A1 | ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |