Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 17/20 | 0.79 |
| ▸ | MMP13 | P45452 | 17/20 | 0.79 |
| ▸ | ADAM17 | P78536 | 17/20 | 0.79 |
| ▸ | MMP9 | P14780 | 15/20 | 0.79 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6289972 | 0.98 | MMP1 (0.81) | MMP1MMP13ADAM17MMP9KEAP1 | |
| SCHEMBL7420153 | 0.89 | MMP1 (0.77) | MMP1MMP13ADAM17MMP9KEAP1 | |
| SCHEMBL7009586 | 0.88 | MMP1 (1.00) | MMP1MMP13ADAM17MMP9 | |
| SCHEMBL6290522 | 0.84 | ADAM17 (0.84) | MMP1MMP13ADAM17MMP9 | |
| SCHEMBL7011701 | 0.82 | MMP1 (0.75) | MMP1MMP13ADAM17MMP9KEAP1 | |
| Hydroxyamine SCHEMBL7485540 | 0.78 | MMP13 (0.52) | MMP1MMP13ADAM17MMP9KEAP1 | |
| SCHEMBL20702345 | 0.77 | MMP1 (0.49) | MMP1MMP13ADAM17MMP9 | |
| SCHEMBL27511019 | 0.77 | KEAP1 (0.57) | MMP1MMP13ADAM17MMP9KEAP1 | |
| Hydroxyamine SCHEMBL7472830 | 0.76 | MMP1 (0.54) | MMP1MMP13ADAM17MMP9KEAP1 | |
| SCHEMBL6293370 | 0.76 | ADAM17 (0.82) | MMP1MMP13ADAM17MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021413-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999018076-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |