Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 5/20 | 0.45 |
| ▸ | CCR4 | P51679 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466587 | 0.83 | CCR4 (0.36) | CCR4MAPTSMN1; SMN2PIK3CDKDM4E | |
| SCHEMBL7462801 | 0.81 | CCR4 (0.36) | CCR4SMN1; SMN2PIK3CDHSD17B10LMNA | |
| SCHEMBL7475650 | 0.73 | CCR4 (0.35) | CCR4MAPTPIK3CDKDM4EHSD17B10 | |
| SCHEMBL7467654 | 0.73 | NPY1R (0.37) | CCR4SMN1; SMN2TSHRPIK3CDHSD17B10 | |
| SCHEMBL7680466 | 0.73 | CYP1A2 (0.39) | MAPTSMN1; SMN2TSHRKDM4EHSD17B10 | |
| SCHEMBL7468793 | 0.72 | CCR4 (0.36) | CCR4SMN1; SMN2PIK3CDHIF1APIK3CG | |
| SCHEMBL7476942 | 0.72 | ALDH1A1 (0.38) | SLC40A1CCR4MAPTSMN1; SMN2TSHR | |
| SCHEMBL7468298 | 0.71 | KMT2A (0.37) | KDM4ELMNAMEN1KMT2A | |
| SCHEMBL5475358 | 0.71 | KDM4E (0.72) | CCR4POLBMAPTSMN1; SMN2PIK3CD | |
| SCHEMBL7682523 | 0.70 | HRH4 (0.33) | MAPTSMN1; SMN2TSHRHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |