Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 10/20 | 0.36 |
| ▸ | LY6K | Q17RY6 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.33 |
| ▸ | GLP1R | P43220 | 1/20 | 0.32 |
| ▸ | SGK1 | O00141 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466587 | 0.86 | CCR4 (0.36) | CCR4HPGDHSD17B10SMN1; SMN2HIF1A | |
| SCHEMBL7472870 | 0.81 | SLC40A1 (0.45) | CCR4LMNAHSD17B10SMN1; SMN2HIF1A | |
| SCHEMBL7472004 | 0.80 | ALDH1A1 (0.36) | CCR4LY6KHPGDLMNAHSD17B10 | |
| SCHEMBL7465420 | 0.78 | SMN1; SMN2 (0.33) | CCR4BRAFLMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL7470948 | 0.77 | GLP1R (0.33) | CCR4HPGDLMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL7475650 | 0.76 | CCR4 (0.35) | CCR4HPGDHSD17B10PIK3CDPIK3CA | |
| SCHEMBL7467654 | 0.76 | NPY1R (0.37) | CCR4HSD17B10SMN1; SMN2HIF1APIK3CD | |
| SCHEMBL7680466 | 0.76 | CYP1A2 (0.39) | HPGDHSD17B10SMN1; SMN2PGK1 | |
| SCHEMBL8935311 | 0.75 | SMN1; SMN2 (0.32) | CCR4BRAFLMNASMN1; SMN2HIF1A | |
| SCHEMBL7470559 | 0.75 | HRH4 (0.32) | PGK1GSK3BMAP4K2GLP1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0783495-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | Pfizer Limited (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |