Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 4/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.33 |
| ▸ | ACLY | P53396 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SGK1 | O00141 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466587 | 0.89 | CCR4 (0.36) | CCR4PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL7468793 | 0.85 | CCR4 (0.36) | CCR4PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL7476942 | 0.85 | ALDH1A1 (0.38) | CCR4PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL7467654 | 0.84 | NPY1R (0.37) | CCR4PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL7470948 | 0.82 | GLP1R (0.33) | CCR4PIK3CAACLYKDM4EMEN1 | |
| SCHEMBL7465420 | 0.81 | SMN1; SMN2 (0.33) | CCR4PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8935311 | 0.78 | SMN1; SMN2 (0.32) | CCR4PIK3CAKDM4EMAPT | |
| SCHEMBL7468982 | 0.77 | ALDH1A1 (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGKDM4E | |
| SCHEMBL8935248 | 0.77 | PIK3CA (0.32) | PIK3CA | |
| SCHEMBL7462801 | 0.76 | CCR4 (0.36) | CCR4PIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0783495-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | Pfizer Limited (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |