Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23123293 | 0.80 | ALDH1A1 (0.48) | TRPC3SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL30986408 | 0.73 | LTA4H (0.45) | SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL21047719 | 0.72 | KDM4C (0.42) | SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL5640283 | 0.69 | CHEK2 (0.71) | SMN1; SMN2NPC1ALDH1A1RAB9AJAK1 | |
| SCHEMBL6555088 | 0.66 | EPHX2 (0.41) | SMN1; SMN2 | |
| SCHEMBL6670248 | 0.65 | LMNA (0.53) | SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL1748039 | 0.65 | NPC1 (0.54) | SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL29745123 | 0.65 | NPC1 (0.54) | SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL3319822 | 0.65 | F10 (0.43) | HRH3 | |
| Hydrochloric Acid SCHEMBL14632558 | 0.65 | F10 (0.47) | HRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-A4 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 1999-07-28 | — | — | EP | disclosed |
| EP-0865281-A1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LABORATORIES, INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997021437-A1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LABORATORIES, INC. (DE) | 1997-06-19 | — | — | WO | disclosed |