Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479928 | 0.90 | POLB (0.51) | KMT2ASMN1; SMN2EPHX2MEN1HTT | |
| SCHEMBL7472773 | 0.86 | KMT2A (0.52) | KMT2ASMN1; SMN2EPHX2MEN1HTT | |
| SCHEMBL30761563 | 0.86 | KMT2A (0.55) | KMT2ASMN1; SMN2EPHX2MEN1HTT | |
| SCHEMBL21436913 | 0.86 | KMT2A (0.55) | KMT2ASMN1; SMN2EPHX2MEN1HTT | |
| SCHEMBL8035779 | 0.84 | KMT2A (0.61) | KMT2ASMN1; SMN2EPHX2MEN1ALDH1A1 | |
| SCHEMBL22639782 | 0.83 | P2RX7 (0.59) | KMT2ASMN1; SMN2EPHX2MEN1HTT | |
| SCHEMBL7597843 | 0.81 | POLB (0.46) | KMT2ASMN1; SMN2EPHX2MEN1HTT | |
| SCHEMBL9341104 | 0.79 | KMT2A (0.83) | KMT2ASMN1; SMN2EPHX2MEN1ALDH1A1 | |
| SCHEMBL31658991 | 0.79 | KMT2A (0.83) | KMT2ASMN1; SMN2EPHX2MEN1ALDH1A1 | |
| SCHEMBL28244458 | 0.78 | KMT2A (0.65) | KMT2ASMN1; SMN2EPHX2MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861077-B1 | HEMOREGULATORY COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2002-02-06 | — | — | EP | claimed |
| EP-0861077-A4 | HEMOREGULATORY COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1999-03-03 | — | — | EP | claimed |
| EP-0861077-A1 | HEMOREGULATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-09-02 | — | — | EP | claimed |
| WO-1997017964-A1 | HEMOREGULATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-22 | — | — | WO | claimed |
| EP-0861077-B1 | HEMOREGULATORY COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2002-02-06 | — | — | EP | disclosed |
| US-6107309-A | BLOOD DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0861077-A4 | HEMOREGULATORY COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0861077-A1 | HEMOREGULATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997017964-A1 | HEMOREGULATORY COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-22 | — | — | WO | disclosed |