Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.45 |
| ▸ | THRA | P10827 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ATF1 | P18846 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.31 |
| ▸ | PDIA4 | P13667 | 1/20 | 0.31 |
| ▸ | PDIA3 | P30101 | 1/20 | 0.31 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5417217 | 0.82 | CRHR1 (0.44) | CRHR1CACNA1HPLK4CHEK1AURKA | |
| SCHEMBL5418708 | 0.81 | CRHR1 (0.42) | CRHR1CACNA1HPLK4CHEK1AURKA | |
| SCHEMBL7482091 | 0.79 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL6202588 | 0.77 | CRHR1 (0.38) | CRHR1THRATHRBPLK4CHEK1 | |
| SCHEMBL7478697 | 0.77 | CRHR1 (0.49) | CRHR1CNR2 | |
| SCHEMBL7475280 | 0.76 | MCHR1 (0.39) | CRHR1 | |
| SCHEMBL7474497 | 0.75 | MCHR1 (0.40) | — | |
| SCHEMBL6200122 | 0.74 | CRHR1 (0.47) | CRHR1CNR2 | |
| SCHEMBL7477213 | 0.71 | CRHR1 (0.39) | CRHR1PLK4CHEK1AURKANTRK1 | |
| SCHEMBL7480028 | 0.71 | CRHR1 (0.47) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |