Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.43 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.33 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480028 | 0.87 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL5411905 | 0.81 | CRHR1 (0.58) | CRHR1ABCC8KCNJ11TRPV3SLC9A5 | |
| SCHEMBL5414396 | 0.80 | CRHR1 (0.45) | CRHR1ABCC8KCNJ11TRPV3SLC9A5 | |
| SCHEMBL7473334 | 0.79 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL5412069 | 0.79 | CRHR1 (0.51) | CRHR1ABCC8KCNJ11TRPV3 | |
| SCHEMBL6201986 | 0.77 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL6200122 | 0.76 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL7483586 | 0.74 | TLR8 (0.41) | CRHR1PDE2A | |
| SCHEMBL7479299 | 0.74 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL7474501 | 0.73 | CRHR1 (0.59) | CRHR1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |