Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HMGCR | P04035 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770315 | 0.81 | MEN1 (0.39) | TSHR | |
| SCHEMBL8099688 | 0.78 | CYP3A4 (0.36) | DGAT1TSHRPPARDTP53TDP1 | |
| SCHEMBL10388660 | 0.75 | TSHR (0.37) | TSHRPPARDTP53TDP1CA12 | |
| SCHEMBL1240221 | 0.74 | CYP3A4 (0.33) | DGAT1TSHRTP53TDP1 | |
| SCHEMBL7674935 | 0.73 | DGAT1 (0.43) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL3473172 | 0.69 | DGAT1 (0.38) | DGAT1CA1CA2 | |
| SCHEMBL14081944 | 0.68 | CA1 (0.42) | DGAT1TSHRPPARDTP53TDP1 | |
| SCHEMBL2923540 | 0.68 | DGAT1 (0.38) | DGAT1TDP1CA12CA1CA2 | |
| SCHEMBL9614639 | 0.68 | TSHR (0.48) | TSHRPPARDTP53TDP1 | |
| SCHEMBL3146731 | 0.68 | TSHR (0.48) | TSHRPPARDTP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790994-B1 | HETEROCYCLE SUBSTITUTED PROPENOIC ACID DERIVATIVES AS NMDA ANTAGONISTS | AVENTIS PHARMA INC (US) | 2002-05-08 | — | — | EP | disclosed |
| US-6180786-B1 | ANTAGONIST FOR EXCITORY AMINO ACIDS | HOECHST MARION ROUSSEL, INC. | 2001-01-30 | — | — | US | disclosed |
| US-5981553-A | BLOCKING EXCITATORY AMINO ACID ACTION IN PREVENTING HUNTINGTON'S DISEASE, ALZHEIMER'S DISEASE, SENILE DEMENTIA, GLUTARIC ACIDAEMIA TYPE I, MULTI-INFARCT DEMENTIA, AMYOTROPHIC LATERAL SCLEROSIS OR NEURONAL DAMAGE FROM SEIZURES | HOECHST MARION ROUSSEL, INC. (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0790994-A1 | HETEROCYCLE SUBSTITUTED PROPENOIC ACID DERIVATIVES AS NMDA ANTAGONISTS | HOECHST MARION ROUSSEL, INC. (US) | 1997-08-27 | — | — | EP | disclosed |
| US-5563157-A | EXCITATORY AMINO ACID ANTAGONISTS | HOECHST MARION ROUSSEL INC. (US) | 1996-10-08 | — | — | US | disclosed |
| US-5519048-A | 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof | MERRELL PHARMACEUTICALS INC. (US) | 1996-05-21 | — | — | US | disclosed |
| WO-1996013501-A1 | HETEROCYCLE SUBSTITUTED PROPENOIC ACID DERIVATIVES AS NMDA ANTAGONISTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-05-09 | — | — | WO | disclosed |