⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308882 | 0.69 | TP53 (0.32) | — | |
| SCHEMBL1649848 | 0.69 | RARA (0.40) | — | |
| SCHEMBL4849018 | 0.66 | RARA (0.32) | — | |
| SCHEMBL6344022 | 0.66 | TP53 (0.36) | — | |
| SCHEMBL9192247 | 0.64 | RARA (0.37) | — | |
| SCHEMBL6350807 | 0.63 | BACE1 (0.36) | — | |
| SCHEMBL8164070 | 0.63 | ALDH1A1 (0.33) | — | |
| SCHEMBL366355 | 0.63 | — | — | |
| SCHEMBL6342498 | 0.62 | RARA (0.33) | — | |
| SCHEMBL6350746 | 0.62 | MEN1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977749-B1 | BI-AROMATIC COMPOUNDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | GALDERMA RES & DEV (FR) | 2002-03-13 | — | — | EP | disclosed |
| EP-0977749-A1 | BI-AROMATIC COMPOUNDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | Galderma Research & Development (FR) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998056783-A1 | BI-AROMATIC COMPOUNDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | GALDERMA RESEARCH & DEVELOPMENT (FR) | 1998-12-17 | — | — | WO | disclosed |