SCHEMBL747355

SCHEMBL747355

CC(C)(O)c1[c]cccc1

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.31
ALDH1A1 P00352 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8133491 0.86 ALDH1A1 (0.30) TSHRALDH1A1TDP1
SCHEMBL4283771 0.83 PDK1 (0.30)
SCHEMBL1503381 0.80 ALDH1A1 (0.30) ALDH1A1
SCHEMBL49872 0.80 ALDH1A1 (0.32) TSHRALDH1A1TDP1
SCHEMBL4799337 0.79 CYP2C19 (0.38) TSHRALDH1A1
SCHEMBL4283774 0.79 PDK1 (0.30)
SCHEMBL2479302 0.79 HSD11B1 (0.39)
SCHEMBL19405600 0.78 TAAR1 (0.30)
SCHEMBL9214276 0.78
SCHEMBL454837 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0328643-B1 (alpha)-HYDROPEROXYISOPROPYLPHENYL COMPOUNDS AND PROCESS FOR THEIR PREPARATION TERUMO CORP (JP) 1994-07-06 EP claimed
US-5043142-A Measuring peroxide-active substances TERUMO KABUSHIKI KAISHA (JP) 1991-08-27 US claimed
EP-0328643-A1 (alpha)-HYDROPEROXYISOPROPYLPHENYL COMPOUNDS AND PROCESS FOR THEIR PREPARATION TERUMO KABUSHIKI KAISHA (JP) 1989-08-23 EP claimed
JP-63274867-A None JP disclosed
JP-63274868-A None JP disclosed
JP-63275559-A None JP disclosed
US-20230149221-A1 WOUND DRESSING SCAPA UK LIMITED (GB) 2023-05-18 US disclosed
EP-3672543-B1 WOUND DRESSING SCAPA UK LTD (GB) 2022-03-02 EP disclosed
US-20210361492-A1 WOUND DRESSING SCAPA UK LIMITED (GB) 2021-11-25 US disclosed
EP-3145556-B1 APERTURED HYDROGEL COMPOSITIONS AND WOUND DRESSINGS FIRST WATER LTD (GB) 2020-11-18 EP disclosed
US-20200354354-A1 BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS XENON PHARMACEUTICALS INC. (CA) 2020-11-12 US disclosed
EP-0328643-B1 (alpha)-HYDROPEROXYISOPROPYLPHENYL COMPOUNDS AND PROCESS FOR THEIR PREPARATION TERUMO CORP (JP) 1994-07-06 EP disclosed
US-5043142-A Measuring peroxide-active substances TERUMO KABUSHIKI KAISHA (JP) 1991-08-27 US disclosed
US-4906662-A Phenol derivatives, their preparation and the use thereof OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 1990-03-06 US disclosed
EP-0328643-A1 (alpha)-HYDROPEROXYISOPROPYLPHENYL COMPOUNDS AND PROCESS FOR THEIR PREPARATION TERUMO KABUSHIKI KAISHA (JP) 1989-08-23 EP disclosed
JP-S63275559-A POLY(ALPHA-HYDROPEROXYISOPROPYLPHENYL) COMPOUND AND PRODUCTION THEREOF TERUMO CORP 1988-11-14 JP disclosed
JP-S63274867-A TEST COMPOSITION FOR MEASURING PEROXIDE ACTIVATING MATERIAL AND TESTING IMPLEMENT DEPOSITED THEREWITH TERUMO CORP 1988-11-11 JP disclosed
JP-S63274868-A ALPHA-HYDROPEROXYISOPROPYL PHENYL COMPOUND AND ITS PRODUCTION TERUMO CORP 1988-11-11 JP disclosed
US-4745176-A FRIEDEL-CRAFTS ALKYLATION BAYER AKTIENGESELLSCHAFT (DE) 1988-05-17 US disclosed
EP-0263229-A1 Phenol derivatives, their preparation and the use thereof OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 1988-04-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200354354-A1 BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS SCN1A, SCN1B, SCN2B TSHR 3451/4885ALDH1A1 2797/4885TDP1 1738/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.