Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473843 | 1.00 | LMNA (0.45) | LMNACHRM1AURKACYP3A4SLC22A1 | |
| SCHEMBL7311417 | 0.92 | LMNA (0.47) | LMNACHRM1AURKACYP3A4SLC22A1 | |
| SCHEMBL7311422 | 0.92 | LMNA (0.47) | LMNACHRM1AURKACYP3A4SLC22A1 | |
| SCHEMBL7472597 | 0.88 | LMNA (0.42) | LMNACHRM1AURKACYP3A4SLC22A1 | |
| SCHEMBL7472591 | 0.88 | LMNA (0.42) | LMNACHRM1AURKACYP3A4SLC22A1 | |
| SCHEMBL7317293 | 0.81 | GABRA1 (0.46) | LMNAOPRK1PDE4D | |
| SCHEMBL7317291 | 0.81 | GABRA1 (0.46) | LMNAOPRK1PDE4D | |
| SCHEMBL11610714 | 0.81 | LMNA (0.47) | LMNACHRM1AURKACYP3A4DRD3 | |
| SCHEMBL7313894 | 0.80 | LMNA (0.44) | LMNACHRM1AURKACYP3A4SLC22A1 | |
| SCHEMBL7307232 | 0.80 | LMNA (0.44) | LMNACHRM1AURKACYP3A4SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1199308-A2 | Process for the preparation of imidazodiazepine intermediates | Abbott Laboratories (US) | 2002-04-24 | — | — | EP | disclosed |
| EP-1105392-A1 | PROCESS FOR THE PREPARATION OF IMIDAZODIAZEPINE INTERMEDIATES | ABBOTT LABORATORIES (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2001000625-A1 | PROCESS FOR THE PREPARATION OF IMIDAZODIAZEPINE INTERMEDIATES | ABBOTT LABORATORIES (US) | 2001-01-04 | — | — | WO | disclosed |