Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.32 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.30 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478336 | 0.92 | MEN1 (0.36) | KMT2AMEN1GAAUSP2KCNE1 | |
| SCHEMBL7467207 | 0.89 | AKR1B1 (0.33) | KMT2AMEN1TRPV1KCNE1KCNQ1 | |
| Hydrochloric Acid SCHEMBL8525004 | 0.89 | MEN1 (0.31) | KMT2AMEN1TRPV1 | |
| SCHEMBL7470193 | 0.83 | KDM4E (0.38) | KMT2AMEN1KCNE1KCNQ1MAPT | |
| SCHEMBL7473128 | 0.81 | KCNE1 (0.33) | KMT2AMEN1TRPV1KCNE1KCNQ1 | |
| SCHEMBL7471976 | 0.81 | KCNE1 (0.33) | KMT2AMEN1KCNE1KCNQ1 | |
| SCHEMBL7477508 | 0.76 | ALOX15 (0.39) | KMT2AMEN1GAAHTTMAPT | |
| SCHEMBL6602312 | 0.74 | MAPT (0.35) | KMT2AMEN1TRPV1KCNE1KCNQ1 | |
| SCHEMBL6559280 | 0.74 | KCNE1 (0.33) | KMT2AMEN1KCNE1KCNQ1MAPT | |
| SCHEMBL7472274 | 0.72 | KCNE1 (0.53) | KMT2AMEN1GAAKCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| US-5955607-A | TREATING CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-09-21 | — | — | US | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |