Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463731 | 0.92 | PIM1 (0.33) | ALDH1A1PIM1 | |
| SCHEMBL7472738 | 0.91 | KDM4E (0.40) | KDM4ETDP1L3MBTL3L3MBTL1HTT | |
| SCHEMBL7463445 | 0.89 | KDM4E (0.43) | KDM4ETDP1L3MBTL3L3MBTL1HTT | |
| SCHEMBL1664709 | 0.86 | — | — | |
| SCHEMBL4831868 | 0.83 | ALDH1A1 (0.34) | KDM4ETDP1L3MBTL3L3MBTL1LMNA | |
| SCHEMBL667548 | 0.82 | L3MBTL1 (0.40) | L3MBTL3L3MBTL1LMNAALDH1A1 | |
| SCHEMBL477164 | 0.82 | L3MBTL1 (0.40) | L3MBTL3L3MBTL1LMNAALDH1A1 | |
| SCHEMBL667276 | 0.82 | L3MBTL1 (0.40) | L3MBTL3L3MBTL1LMNAALDH1A1 | |
| SCHEMBL1489870 | 0.80 | L3MBTL3 (0.39) | L3MBTL3L3MBTL1LMNAALDH1A1 | |
| SCHEMBL1489973 | 0.80 | L3MBTL3 (0.39) | L3MBTL3L3MBTL1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858452-B1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2002-03-13 | — | — | EP | disclosed |
| US-6140330-A | USEFUL AS PROTEIN KINASE INHIBITOR; FOR TREATMENT OF AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS, SYSTEMIC LUPUS ERYTHEMATOSUS, MULTIPLE SCLEROSIS, PSORIASIS, ETC., VARIOUS ALLERGIC DISEASES SUCH AS CROHN'S DISEASE, ASTHMA | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2000-10-31 | — | — | US | disclosed |
| EP-0858452-A1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-19 | — | — | EP | disclosed |
| WO-1998004536-A1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1998-02-05 | — | — | WO | disclosed |