Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.54 |
| ▸ | CDC25B | P30305 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CDC25A | P30304 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946566 | 0.91 | AKR1C3 (0.57) | ALDH1A1KDM4EPOLBGAAAKR1C3 | |
| SCHEMBL10637741 | 0.88 | POLB (0.58) | ALDH1A1KDM4EPOLBGAAAKR1C3 | |
| SCHEMBL5281386 | 0.86 | HPGD (0.56) | ALDH1A1KDM4EPOLBGAAEGFR | |
| SCHEMBL1977600 | 0.85 | MEN1 (0.65) | ALDH1A1KDM4EPOLBGAAAKR1C3 | |
| SCHEMBL1827424 | 0.83 | EGFR (0.59) | ALDH1A1KDM4EPOLBGAAEGFR | |
| SCHEMBL472266 | 0.81 | EGFR (0.58) | ALDH1A1KDM4EPOLBGAAEGFR | |
| SCHEMBL267885 | 0.81 | ALDH1A1 (1.00) | ALDH1A1KDM4EPOLBGAACDC25B | |
| SCHEMBL16937421 | 0.81 | RAB9A (0.53) | ALDH1A1KDM4EPOLBGAAEGFR | |
| SCHEMBL1962996 | 0.81 | RAB9A (0.53) | ALDH1A1KDM4EPOLBGAAEGFR | |
| SCHEMBL10637704 | 0.80 | AKR1C3 (0.48) | ALDH1A1KDM4EPOLBGAAAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10711027-B2 | DNA polymerase beta inhibitors | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-07-14 | — | — | US | disclosed |
| US-20190202853-A1 | DNA POLYMERASE BETA INHIBITORS | THE JOHNS HOPKINS UNIVERSITY | 2019-07-04 | — | — | US | disclosed |
| EP-0664292-B1 | A phtalide compound and a near infrared absorber and a recording material each comprising the same compound | YAMAMOTO CHEMICALS INC (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5627287-A | COLORLESS | YAMAMOTO CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0664292-A1 | A phtalide compound and a near infrared absorber and a recording material each comprising the same compound | YAMAMOTO CHEMICALS, INC. (JP) | 1995-07-26 | — | — | EP | disclosed |
| EP-0581589-A2 | Phthalide compounds, and recording materials using the compounds | YAMAMOTO CHEMICALS, INC. (JP) | 1994-02-02 | — | — | EP | disclosed |
| EP-0107780-B1 | FLUORAN COMPOUNDS | HODOGAYA CHEMICAL CO., LTD. (JP) | 1987-11-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10711027-B2 | DNA polymerase beta inhibitors | POLB, POLH, POLN | ALDH1A1 908/4885KDM4E 3702/4885POLB 1/4885 |
| US-20190202853-A1 | DNA POLYMERASE BETA INHIBITORS | POLB, POLH, POLN | ALDH1A1 908/4885KDM4E 3702/4885POLB 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.