Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31374594 | 0.80 | AOC3 (0.39) | HTR2AHRH1ALDH1A1TDP1KDM4E | |
| SCHEMBL7482504 | 0.75 | CYP2C19 (0.51) | ALDH1A1TDP1KDM4EMAPTKMT2A | |
| SCHEMBL7306332 | 0.72 | CYP2C19 (0.41) | ALDH1A1TDP1KDM4EMAPTKMT2A | |
| SCHEMBL7476459 | 0.71 | ALDH1A1 (0.45) | ALDH1A1MAPTKMT2ALMNAPOLB | |
| SCHEMBL7308150 | 0.70 | KCNA5 (0.44) | ALDH1A1TDP1KDM4EMAPTKMT2A | |
| SCHEMBL7317708 | 0.70 | MMP3 (0.53) | ALDH1A1TDP1KDM4EMAPTKMT2A | |
| Water SCHEMBL28355612 | 0.69 | CHRNA7 (0.56) | HTR2AHRH1ALDH1A1TDP1KDM4E | |
| SCHEMBL10564457 | 0.68 | MAOB (0.42) | HTR2AHRH1ALDH1A1TDP1KDM4E | |
| SCHEMBL6638318 | 0.68 | SRC (0.42) | ALDH1A1TDP1KDM4EMAPTKMT2A | |
| SCHEMBL10584824 | 0.67 | HTR2A (0.41) | HTR2AHRH1ALDH1A1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975594-B1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | PFIZER LTD (GB) | 2002-09-18 | — | — | EP | disclosed |
| US-6281357-B1 | HEADACHE THERAPY | PFIZER INC | 2001-08-28 | — | — | US | disclosed |
| EP-0975594-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | Pfizer Limited (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1999002493-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | PFIZER LIMITED (GB) | 1999-01-21 | — | — | WO | disclosed |