Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | MC3R | P41968 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482504 | 0.87 | CYP2C19 (0.51) | CYP2C19GAANPSR1SRCLMNA | |
| SCHEMBL7308150 | 0.81 | KCNA5 (0.44) | CYP2C19GAANPSR1SMN1; SMN2LMNA | |
| SCHEMBL7317708 | 0.81 | MMP3 (0.53) | CYP2C19NPSR1SLC6A3LMNAKMT2A | |
| SCHEMBL6638318 | 0.73 | SRC (0.42) | CYP2C19GAANPSR1SMN1; SMN2SRC | |
| SCHEMBL7478269 | 0.72 | MMP3 (0.57) | SMN1; SMN2LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL7474205 | 0.72 | HTR2A (0.36) | NPSR1SRCSLC6A3LMNAKMT2A | |
| SCHEMBL1537325 | 0.70 | CYP2C19 (0.72) | CYP2C19NPSR1CYP1A2CYP2D6PKM | |
| SCHEMBL7302947 | 0.70 | MMP3 (0.59) | KMT2AMEN1AOC3TDP1 | |
| SCHEMBL7315311 | 0.70 | MAPT (0.43) | CYP2C19DRD3DRD2KMT2AALDH1A1 | |
| SCHEMBL28387966 | 0.70 | MEN1 (0.54) | GAANPSR1CYP2D6PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931788-B1 | Metalloprotease inhibitors | PFIZER LTD (GB) | 2002-11-06 | — | — | EP | disclosed |
| EP-0975594-B1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | PFIZER LTD (GB) | 2002-09-18 | — | — | EP | disclosed |
| US-6281357-B1 | HEADACHE THERAPY | PFIZER INC | 2001-08-28 | — | — | US | disclosed |
| US-6090852-A | MATRIX METALLOPROTEASE INHIBITOR | PFIZER INC (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0975594-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | Pfizer Limited (GB) | 2000-02-02 | — | — | EP | disclosed |
| EP-0931788-A2 | Metalloprotease inhibitors | Pfizer Limited (GB) | 1999-07-28 | — | — | EP | disclosed |
| WO-1999002493-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | PFIZER LIMITED (GB) | 1999-01-21 | — | — | WO | disclosed |