Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 6/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 10/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 10/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474225 | 1.00 | KCNA5 (0.41) | KCNA5KCNE1KCNQ1ABCB1MEN1 | |
| SCHEMBL7474233 | 1.00 | KCNA5 (0.41) | KCNA5KCNE1KCNQ1ABCB1MEN1 | |
| SCHEMBL2824110 | 0.83 | SELL (0.39) | KCNA5KCNE1KCNQ1ABCB1CYP3A4 | |
| SCHEMBL9197844 | 0.80 | HTR1A (0.39) | KCNE1KCNQ1ABCB1MEN1CYP1A2 | |
| SCHEMBL9197856 | 0.80 | HTR1A (0.39) | KCNE1KCNQ1ABCB1MEN1CYP1A2 | |
| SCHEMBL9197846 | 0.80 | HTR1A (0.39) | KCNE1KCNQ1ABCB1MEN1CYP1A2 | |
| SCHEMBL9363912 | 0.79 | KCNA5 (0.49) | KCNA5ABCB1 | |
| SCHEMBL9581830 | 0.79 | KCNA5 (0.39) | KCNA5KCNE1KCNQ1ABCB1MEN1 | |
| SCHEMBL9581848 | 0.79 | KCNA5 (0.39) | KCNA5KCNE1KCNQ1ABCB1MEN1 | |
| SCHEMBL9581839 | 0.79 | KCNA5 (0.39) | KCNA5KCNE1KCNQ1ABCB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0587645-B1 | BENZO- AND PYRIDOPYRAN DERIVATIVES HAVING ANXIOLYTIC AND ANTI-CONVULSANT ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2002-02-27 | — | — | EP | disclosed |
| EP-1108718-A2 | Trans-6-Acetyl-4S-(4-fluorobenzoylamino)-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3R-ol | SMITHKLINE BEECHAM PLC (GB) | 2001-06-20 | — | — | EP | disclosed |
| US-5889044-A | Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-03-30 | — | — | US | disclosed |
| US-5624954-A | Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-04-29 | — | — | US | disclosed |
| EP-0426379-B1 | Substituted cyclobutenedione compounds | BEECHAM GROUP PLC (GB) | 1994-12-21 | — | — | EP | disclosed |
| EP-0412760-B1 | Benzopyran derivatives | BEECHAM GROUP PLC (GB) | 1994-11-23 | — | — | EP | disclosed |
| WO-1994012173-A1 | BENZOPYRON ANALOGUES FOR THE TREATMENT OF ANXIETY, MANIA, DEPRESSION OR WITHDRAWAL SYMPTOMS | SMITHKLINE BEECHAM PLC (GB) | 1994-06-09 | — | — | WO | disclosed |
| US-5232938-A | For treatment of respiratory tract disorders, hypertension and urinary tract disorders | BEECHAM GROUP P.L.C. (GB) | 1993-08-03 | — | — | US | disclosed |
| EP-0536424-A1 | NOVEL BENZOPYRAN DERIVATIVE | Japan Tobacco Inc. (JP) | 1993-04-14 | — | — | EP | disclosed |
| US-5147866-A | Hypotensive, bronchodilator agents | BEECHAM GROUP P.L.C. (GB) | 1992-09-15 | — | — | US | disclosed |
| EP-0426379-A2 | Substituted cyclobutenedione compounds | Beecham Group p.l.c. (GB) | 1991-05-08 | — | — | EP | disclosed |
| EP-0412760-A2 | Benzopyran derivatives | Beecham Group p.l.c. (GB) | 1991-02-13 | — | — | EP | disclosed |