SCHEMBL7474470

SCHEMBL7474470

O=C1c2ccccc2C(=O)N1Nc1ccncc1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.46
LMNA P02545 1/20 0.44
HTT P42858 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
CTDSP1 Q9GZU7 1/20 0.40
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
FFAR4 Q5NUL3 1/20 0.39
GAA P10253 1/20 0.37
ALOX15 P16050 1/20 0.37
ALDH1A1 P00352 1/20 0.36
F10 P00742 1/20 0.36
F7 P08709 1/20 0.36
F3 P13726 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
POLB P06746 3/20 0.35
TSHR P16473 1/20 0.35
SLC22A12 Q96S37 1/20 0.35
HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27368903 0.80 CYP1A2 (0.55) CYP1A2HTTMEN1KMT2ACTDSP1
SCHEMBL8860096 0.75 HPGD (0.37) MEN1KMT2AHPGD
SCHEMBL7485009 0.73 CYP1A2 (0.71) CYP1A2LMNAHTTGAAALDH1A1
SCHEMBL8860185 0.73 MEN1 (0.34) LMNAMEN1KMT2ASMN1; SMN2
SCHEMBL7608055 0.71 TGFBR1 (0.38)
SCHEMBL7480165 0.70 TGFBR1 (0.35) LMNAHPGD
SCHEMBL9663897 0.70 SLC6A2 (0.56) MAOAMAOB
Hydrochloric Acid SCHEMBL9665059 0.69 SLC6A2 (0.54) MAOAMAOB
Hydrochloric Acid SCHEMBL7484530 0.69 TGFBR1 (0.34) LMNA
SCHEMBL20515677 0.67 CYP1A2 (0.57) CYP1A2LMNAHTTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP claimed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP claimed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO claimed
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
US-6004977-A ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP disclosed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO disclosed