Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 16/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 14/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9791981 | 0.78 | AOC1 (0.37) | TGFBR1 | |
| Hydrochloric Acid SCHEMBL9469543 | 0.76 | AOC1 (0.39) | TGFBR1 | |
| SCHEMBL9470270 | 0.75 | ALDH1A1 (0.57) | — | |
| SCHEMBL7613220 | 0.73 | SLC6A2 (0.59) | TGFBR1TGFBR2BCHEACHE | |
| SCHEMBL9663897 | 0.73 | SLC6A2 (0.56) | TGFBR1TGFBR2BCHEACHE | |
| SCHEMBL7480165 | 0.73 | TGFBR1 (0.35) | TGFBR1TGFBR2LOXL2BCHEACHE | |
| Hydrochloric Acid SCHEMBL7610857 | 0.72 | SLC6A2 (0.57) | TGFBR1TGFBR2BCHEACHE | |
| SCHEMBL7474470 | 0.71 | CYP1A2 (0.46) | — | |
| Hydrochloric Acid SCHEMBL9665059 | 0.71 | SLC6A2 (0.54) | TGFBR1TGFBR2BCHEACHE | |
| Hydrochloric Acid SCHEMBL7484530 | 0.71 | TGFBR1 (0.34) | TGFBR1TGFBR2LOXL2BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1184969-C | Use of unsubstd and substd. N-(pyrrol-1-yl) pyridinamines as anticonvulsant agents | AVENTIS PHARMA INC (US) | 2005-01-19 | — | — | CN | disclosed |
| EP-0840609-B1 | USE OF UNSUBSTITUTED AND SUBSTITUTED N-(PYRROL-1-YL)PYRIDINAMINES AS ANTICONVULSANT AGENTS | AVENTIS PHARMA INC (US) | 2002-06-05 | — | — | EP | disclosed |
| CN-1191486-A | Use of unsubstituted and substituted N- (pyrrol-1-yl) pyridinamines as anticonvulsants | HOECHST MARION ROUSSEL INC (US) | 1998-08-26 | — | — | CN | disclosed |
| US-5776955-A | Use of unsubstituted and substituted n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents | HOECHST MARION ROUSSEL, INC. | 1998-07-07 | — | — | US | disclosed |
| EP-0840609-A1 | USE OF UNSUBSTITUTED AND SUBSTITUTED N-(PYRROL-1-YL)PYRIDINAMINES AS ANTICONVULSANT AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997004777-A1 | USE OFF UNSUBSTITUTED AND SUBSTITUTED N-(PYRROL-1-YL)PYRIDINAMINES AS ANTICONVULSANT AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1997-02-13 | — | — | WO | disclosed |