Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | MYC | P01106 | 4/20 | 0.48 |
| ▸ | MAX | P61244 | 3/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430233 | 0.86 | ALDH1A1 (0.58) | ALDH1A1POLBRAB9AKMT2AMEN1 | |
| SCHEMBL7480971 | 0.83 | ALDH1A1 (0.51) | ALDH1A1POLBLMNAAGTR1RAB9A | |
| SCHEMBL7376464 | 0.81 | MYC (0.52) | ALDH1A1LMNAAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL7373903 | 0.80 | ALDH1A1 (0.52) | ALDH1A1POLBLMNAAGTR1RAB9A | |
| SCHEMBL7342694 | 0.79 | MYC (0.68) | ALDH1A1AKR1C3AKR1C2AKR1C1MYC | |
| SCHEMBL7426873 | 0.79 | POLB (0.44) | ALDH1A1POLBLMNAAGTR1AKR1C3 | |
| SCHEMBL7343440 | 0.76 | MAPT (0.49) | ALDH1A1POLBLMNAAKR1C3AKR1C2 | |
| SCHEMBL7337537 | 0.75 | AR (0.61) | ALDH1A1LMNAAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL7372078 | 0.75 | AR (0.58) | ALDH1A1LMNAMYCMAXAR | |
| SCHEMBL25039190 | 0.75 | RAB9A (0.54) | ALDH1A1POLBLMNAAGTR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| EP-0946519-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024771-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-11 | — | — | WO | disclosed |