Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4312809 | 0.96 | CYP2C19 (0.49) | CYP2C19HTR3EHTR3BADRB1DRD2 | |
| SCHEMBL7469509 | 0.88 | HTR2C (0.46) | CYP2C19ADRB1HTR6MAPTHTR1A | |
| SCHEMBL4317318 | 0.87 | HTR6 (0.45) | CYP2C19HTR3EHTR3BADRB1DRD2 | |
| SCHEMBL4311425 | 0.86 | HTR1A (0.44) | CYP2C19HTR3EHTR3BADRB1DRD2 | |
| SCHEMBL4313354 | 0.85 | POLB (0.45) | CYP2C19HTR3EHTR3BADRB1DRD2 | |
| SCHEMBL2639856 | 0.85 | HTR1A (0.46) | CYP2C19HTR3EHTR3BADRB1DRD2 | |
| SCHEMBL7477223 | 0.85 | PDE10A (0.40) | LMNAHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7476039 | 0.84 | KDM4E (0.45) | DRD2DRD3HTR7HTR1AALDH1A1 | |
| SCHEMBL4314845 | 0.84 | HTR2C (0.47) | CYP2C19ADRB1HTR6MAPTHTR1A | |
| SCHEMBL6046287 | 0.84 | CCNT1 (0.42) | CYP2C19HTR3EHTR3BADRB1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178973-A2 | NOVEL COMPOUNDS, THEIR USE AND PREPARATION | Pharmacia AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000076984-A2 | NOVEL COMPOUNDS, THEIR USE AND PREPARATION | BIOVITRUM AB (SE) | 2000-12-21 | — | — | WO | disclosed |