Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.57 |
| ▸ | PRKCA | P17252 | 3/20 | 0.57 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.57 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | PAM | P19021 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycol Distearate SCHEMBL7615343 | 1.00 | DGKA (0.75) | DGKAMAPTLMNAKDM4EDUSP3 | |
| Ethylene Glycol Dioctanoate SCHEMBL751266 | 1.00 | DGKA (0.75) | DGKAMAPTLMNAKDM4EDUSP3 | |
| Cetyl Palmitate SCHEMBL8103871 | 0.95 | MAPT (0.67) | DGKAMAPTLMNAKDM4EDUSP3 | |
| Propylene Glycol SCHEMBL10635385 | 0.92 | MAPT (0.63) | DGKAMAPTLMNAKDM4EDUSP3 | |
| Propylene Glycol SCHEMBL10781715 | 0.91 | MAPT (0.61) | DGKAMAPTLMNAKDM4EDUSP3 | |
| Nonanoate SCHEMBL11334380 | 0.89 | MAPT (0.59) | DGKAMAPTLMNAKDM4EDUSP3 | |
| Stearic Acid SCHEMBL1565480 | 0.89 | MAPT (0.59) | DGKAMAPTLMNAKDM4EDUSP3 | |
| Propylene Glycol Monostearate SCHEMBL11589103 | 0.88 | MAPT (0.90) | DGKAMAPTLMNAKDM4EDUSP3 | |
| Propylene Glycol SCHEMBL3273044 | 0.88 | MAPT (0.90) | DGKAMAPTLMNAKDM4EDUSP3 | |
| Propylene Glycol SCHEMBL709153 | 0.88 | MAPT (0.90) | DGKAMAPTLMNAKDM4EDUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2429498-A2 | NEW ORAL FORMULATIONS FOR TETRAPYRROLE DERIVATIVES | CeramOptec GmbH (DE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010129337-A2 | NEW ORAL FORMULATIONS FOR TETRAPYRROLE DERIVATIVES | CERAMOPTEC INDUSTRIES, INC. (US) | 2010-11-11 | — | — | WO | disclosed |