Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.47 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DUSP4 | Q13115 | 1/20 | 0.40 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476566 | 0.75 | GABRA1 (0.71) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL497285 | 0.75 | NPC1 (0.69) | RXFP1L3MBTL1GABRG2GABRB3GABRA5 | |
| SCHEMBL7486883 | 0.74 | RXFP1 (0.44) | RXFP1L3MBTL1GABRG2GABRB3GABRA5 | |
| SCHEMBL7479574 | 0.74 | RXFP1 (0.56) | RXFP1L3MBTL1GABRG2GABRB3GABRA5 | |
| SCHEMBL7545847 | 0.74 | GABRG2 (0.55) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL2830794 | 0.73 | RXFP1 (0.62) | RXFP1L3MBTL1GABRG2GABRB3GABRA5 | |
| SCHEMBL31058084 | 0.72 | GABRA1 (0.58) | RXFP1L3MBTL1GABRG2GABRB3GABRA5 | |
| SCHEMBL1258627 | 0.72 | GABRA1 (0.58) | RXFP1L3MBTL1GABRG2GABRB3GABRA5 | |
| SCHEMBL7670642 | 0.72 | DCTPP1 (0.44) | GABRG2GABRB3GABRA3GABRA2GABRA1 | |
| SCHEMBL497344 | 0.71 | RXFP1 (0.65) | RXFP1L3MBTL1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986562-B1 | SUBSTITUTED 1,2,4-TRIAZOLO 3,4-A]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS | MERCK SHARP & DOHME (GB) | 2002-08-07 | — | — | EP | disclosed |
| US-6310203-B1 | Precursor compounds to substituted 1,2,4-triazolo[3,4,-a]phathalazine GABA alpha 5 ligands | MERCK SHARPE & DOHME LIMITED (GB) | 2001-10-30 | — | — | US | disclosed |
| US-6200975-B1 | FOR COGNITION ENHANCEMENT THERAPY | MERCK SHARP & DOHME LIMITED (GB) | 2001-03-13 | — | — | US | disclosed |
| EP-0986562-A1 | SUBSTITUTED 1,2,4-TRIAZOLO 3,4-A]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998050385-A1 | SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1998-11-12 | — | — | WO | disclosed |