Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 4/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476749 | 0.88 | RET (0.42) | PAK1RET | |
| SCHEMBL7475213 | 0.82 | RET (0.43) | RETCHEK1TLK2 | |
| SCHEMBL6340191 | 0.82 | ACHE (0.42) | ACHEPAK1RETCHEK1MAPK1 | |
| SCHEMBL7474781 | 0.79 | RET (0.50) | RETTLK2 | |
| SCHEMBL7480965 | 0.79 | RET (0.45) | RETTLK2 | |
| SCHEMBL7475792 | 0.78 | RET (0.48) | ACHERETTLK2 | |
| SCHEMBL7472918 | 0.77 | RET (0.54) | PAK1RETTLK2 | |
| SCHEMBL7473364 | 0.76 | RET (0.47) | PAK1RETCHEK1TLK2 | |
| SCHEMBL7473409 | 0.76 | TLK2 (0.44) | RETCHEK1TLK2 | |
| SCHEMBL6340195 | 0.76 | ACHE (0.42) | ACHECHEK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |