Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.66 |
| ▸ | SRC | P12931 | 9/20 | 0.66 |
| ▸ | ZAP70 | P43403 | 9/20 | 0.66 |
| ▸ | CDK2 | P24941 | 5/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470877 | 0.90 | CDK2 (0.70) | SYKSRCZAP70CDK2CYP1A2 | |
| SCHEMBL7471621 | 0.83 | MEN1 (0.59) | SYKCDK2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7475248 | 0.80 | PLK1 (0.58) | SYKCDK2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL13924509 | 0.80 | SYK (1.00) | SYKSRCZAP70CDK2 | |
| SCHEMBL7466134 | 0.79 | MEN1 (0.62) | SYKSRCZAP70CDK2CYP1A2 | |
| SCHEMBL7469184 | 0.79 | SYK (0.54) | SYKSRCZAP70CDK2CYP1A2 | |
| SCHEMBL7471189 | 0.79 | SYK (0.50) | SYKSRCZAP70CDK2CYP1A2 | |
| SCHEMBL7468142 | 0.79 | PIK3CG (0.67) | SYKSRCZAP70CDK2CYP1A2 | |
| SCHEMBL13181310 | 0.78 | ZAP70 (0.61) | SYKSRCZAP70CDK2CDK4 | |
| SCHEMBL12423148 | 0.78 | ZAP70 (0.61) | SYKSRCZAP70CDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |