Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 2/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475447 | 0.74 | GRIA1 (0.47) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7477390 | 0.71 | GRIA1 (0.51) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL17193340 | 0.71 | NPC1 (0.60) | NPC1RAB9AHSD11B1ALDH1A1CYP2C19 | |
| SCHEMBL2045062 | 0.68 | NPC1 (0.59) | NPC1RAB9AHSD11B1ALDH1A1CYP2C19 | |
| SCHEMBL7469275 | 0.68 | GRIA2 (0.47) | GRIA2GRIA1GRIA3HSD11B1GRIA4 | |
| SCHEMBL6820817 | 0.68 | NPC1 (0.53) | NPC1RAB9AHSD11B1SCN5AALDH1A1 | |
| SCHEMBL6820957 | 0.67 | ALDH1A1 (0.46) | NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL7468911 | 0.67 | GRIA4 (0.53) | GRIA2GRIA1GRIA3NPC1RAB9A | |
| SCHEMBL7652726 | 0.67 | ALDH1A1 (0.53) | GRIA2GRIA1GRIA3GRIA4MMP1 | |
| SCHEMBL7373187 | 0.66 | RAB9A (0.56) | NPC1RAB9AHSD11B1ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | disclosed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |