SCHEMBL7475437

SCHEMBL7475437

CCOC(=O)C(C)Oc1c(COc2ccc3oc(-c4nc(C(C)(C)C)cs4)cc3c2)cccc1OC

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
LMNA P02545 2/20 0.33
HSP90AA1 P07900 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
F2RL3 Q96RI0 1/20 0.33
PARP10 Q53GL7 2/20 0.32
MAOB P27338 2/20 0.32
PARP15 Q460N3 1/20 0.32
PPARD Q03181 2/20 0.32
PPARA Q07869 1/20 0.32
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
S1PR1 P21453 2/20 0.32
PARP14 Q460N5 1/20 0.31
MAOA P21397 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6598704 0.92 SHMT2 (0.34) F2RL3PARP10MAOBPARP15PPARD
SCHEMBL6597022 0.92 SHMT2 (0.34) F2RL3PARP10MAOBPARP15PPARD
SCHEMBL7477783 0.92 SHMT2 (0.34) F2RL3PARP10MAOBPARP15PPARD
SCHEMBL6598955 0.91 MAOA (0.36) F2RL3PARP10MAOBPARP15PPARD
SCHEMBL6599848 0.91 F2RL3 (0.34) MAPTNPC1RAB9AF2RL3PARP10
SCHEMBL7476179 0.85 F2RL3 (0.33) MAPTNPC1RAB9AF2RL3KDM4E
SCHEMBL6603232 0.84 PARP10 (0.38) F2RL3PARP10MAOBPARP15PPARD
SCHEMBL7480046 0.82 F2RL3 (0.31) F2RL3
SCHEMBL8310234 0.82 SLC26A4 (0.36) MAPTLMNAF2RL3MAOBALDH1A1
SCHEMBL6597755 0.79 KDM4E (0.36) MAPTNPC1RAB9AF2RL3PPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0880519-B1 THIAZOLYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FUJISAWA PHARMACEUTICAL CO (JP) 2002-04-17 EP disclosed
EP-1170009-A2 Thiazolybenzofuran derivatives and their use as SRS-A and leukotiene antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-01-09 EP disclosed
US-5994378-A ANTIALLERGENS; ANTIINFLAMMATORY AGENTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
EP-0880519-A1 THIAZOLYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-12-02 EP disclosed
WO-1997027190-A1 THIAZOLYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-07-31 WO disclosed