Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4290054 | 1.00 | NPC1 (0.66) | NPC1RAB9AHTTALDH1A1ALOX12 | |
| SCHEMBL5123025 | 0.91 | NPC1 (0.60) | NPC1RAB9AHTTALDH1A1ALOX12 | |
| SCHEMBL2584410 | 0.86 | ALDH1A1 (0.65) | NPC1RAB9AALDH1A1ALOX12GLA | |
| SCHEMBL5161443 | 0.86 | NPC1 (0.87) | NPC1RAB9AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL5382549 | 0.84 | ACACB (0.56) | NPC1RAB9AHTT | |
| SCHEMBL1593472 | 0.84 | ACACB (0.56) | NPC1RAB9AHTT | |
| SCHEMBL5126108 | 0.83 | NPC1 (0.54) | NPC1RAB9AHTTALDH1A1ALOX12 | |
| SCHEMBL5126653 | 0.81 | SMN1; SMN2 (0.53) | NPC1RAB9AHTTALDH1A1ALOX12 | |
| SCHEMBL1594519 | 0.81 | ALDH1A1 (0.56) | NPC1RAB9AALDH1A1ALOX12GLA | |
| SCHEMBL7474517 | 0.80 | RAB9A (0.65) | NPC1RAB9AHTTALDH1A1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194421-A4 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1194421-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001002379-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |