Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5407472 | 0.81 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL7477918 | 0.80 | CRHR1 (0.70) | CRHR1ALDH1A1POLB | |
| SCHEMBL7479339 | 0.76 | CRHR1 (0.54) | CRHR1TLR7 | |
| SCHEMBL7477860 | 0.75 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL7480941 | 0.75 | CRHR1 (0.68) | CRHR1TLR7 | |
| SCHEMBL6201786 | 0.75 | CRHR1 (0.60) | CRHR1BRD4 | |
| SCHEMBL6168389 | 0.74 | KDM4E (0.41) | CRHR1TLR7ALDH1A1 | |
| SCHEMBL6203614 | 0.74 | CRHR1 (0.70) | CRHR1BRD4 | |
| SCHEMBL5417279 | 0.74 | TLR7 (0.47) | CRHR1TLR7TLR8CYP1A2CYP3A4 | |
| SCHEMBL7477682 | 0.73 | CRHR1 (0.57) | CRHR1ALDH1A1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |