Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARBP2 | Q15633 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TDP2 | O95551 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | GLP1R | P43220 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12416429 | 0.81 | ALDH1A1 (0.50) | TARBP2ALDH1A1TDP2MLYCDHTT | |
| SCHEMBL19459399 | 0.80 | ALDH1A1 (0.43) | TARBP2ALDH1A1TDP2MLYCDHTT | |
| SCHEMBL17256574 | 0.79 | ALDH1A1 (0.40) | TARBP2ALDH1A1TDP2MLYCDMAPT | |
| SCHEMBL766573 | 0.79 | TARBP2 (0.42) | TARBP2ALDH1A1TDP2MLYCDHTT | |
| SCHEMBL27594096 | 0.79 | ALDH1A1 (0.46) | ALDH1A1TDP2NPC1MLYCDMAPT | |
| SCHEMBL17256473 | 0.78 | MLYCD (0.40) | TARBP2ALDH1A1TDP2NPC1MLYCD | |
| SCHEMBL30450114 | 0.77 | ALDH1A1 (0.41) | TARBP2ALDH1A1TDP2MLYCDMAPT | |
| SCHEMBL19210109 | 0.76 | ALDH1A1 (0.40) | TARBP2ALDH1A1TDP2MLYCDHTT | |
| SCHEMBL32659821 | 0.76 | MLYCD (0.41) | TARBP2ALDH1A1TDP2NPC1MLYCD | |
| SCHEMBL18936195 | 0.76 | ALDH1A1 (0.40) | ALDH1A1TDP2MLYCDMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986562-B1 | SUBSTITUTED 1,2,4-TRIAZOLO 3,4-A]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS | MERCK SHARP & DOHME (GB) | 2002-08-07 | — | — | EP | disclosed |
| US-6310203-B1 | Precursor compounds to substituted 1,2,4-triazolo[3,4,-a]phathalazine GABA alpha 5 ligands | MERCK SHARPE & DOHME LIMITED (GB) | 2001-10-30 | — | — | US | disclosed |
| US-6200975-B1 | FOR COGNITION ENHANCEMENT THERAPY | MERCK SHARP & DOHME LIMITED (GB) | 2001-03-13 | — | — | US | disclosed |