Sugi Predict

Sugi Predict / Compounds / SCHEMBL766573

SCHEMBL766573

SCHEMBL766573

CCOC(=O)c1noc(Br)c1C

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TARBP2 Q15633 2/20 0.42
▸ ALDH1A1 P00352 4/20 0.42
▸ KDM4E B2RXH2 1/20 0.40
▸ POLB P06746 1/20 0.40
▸ PKM P14618 1/20 0.40
▸ TDP2 O95551 2/20 0.40
▸ MLYCD O95822 1/20 0.40
▸ HTR2C P28335 1/20 0.39
▸ CYP1A2 P05177 2/20 0.39
▸ CACNA1F O60840 1/20 0.38
▸ CACNA1D Q01668 1/20 0.38
▸ CACNA1S Q13698 1/20 0.38
▸ CACNA1C Q13936 1/20 0.38
▸ HTT P42858 3/20 0.38
▸ CYP2C9 P11712 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19459399 0.84 ALDH1A1 (0.43) TARBP2ALDH1A1TDP2MLYCDHTR2C
SCHEMBL32659821 0.83 MLYCD (0.41) TARBP2ALDH1A1KDM4EPOLBPKM
SCHEMBL17263226 0.82 TDP2 (0.33) TARBP2ALDH1A1KDM4EPOLBPKM
SCHEMBL12416429 0.81 ALDH1A1 (0.50) TARBP2ALDH1A1POLBTDP2MLYCD
SCHEMBL10821231 0.81 ALDH1A1 (0.45) TARBP2ALDH1A1KDM4EPOLBPKM
SCHEMBL19210109 0.79 ALDH1A1 (0.40) TARBP2ALDH1A1KDM4EPOLBPKM
SCHEMBL768462 0.79 ALDH1A1 (0.33) ALDH1A1POLB
SCHEMBL7476027 0.79 TARBP2 (0.42) TARBP2ALDH1A1KDM4ETDP2MLYCD
SCHEMBL12416482 0.79 ALDH1A1 (0.48) TARBP2ALDH1A1KDM4EPOLBPKM
SCHEMBL10627069 0.79 TARBP2 (0.42) TARBP2ALDH1A1KDM4EPOLBPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025224249-A1 COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF MONTE ROSA THERAPEUTICS AG (CH) 2025-10-30 — — WO disclosed
US-12325702-B2 ATF6 inhibitors and uses thereof ALTOS LABS, INC. (US) 2025-06-10 — — US disclosed
US-20250179061-A1 RIP1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2025-06-05 — — US disclosed
WO-2025104701-A1 AMIDO HETEROAROMATIC COMPOUNDS ASTRAZENECA AB (SE) 2025-05-22 — — WO disclosed
EP-4486743-A1 RIP1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd (KY) 2025-01-08 — — EP disclosed
CN-119060036-A ATF6 inhibitors and uses thereof 阿尔托斯实验室公司 2024-12-03 — — CN disclosed
CN-118765280-A RIP1 modulators, their preparation and use 维泰瑞隆有限公司 2024-10-11 — — CN disclosed
CN-112313224-B ATF6 inhibitors and uses thereof 阿尔托斯实验室公司 2024-08-13 — — CN disclosed
US-20240124434-A1 ATF6 INHIBITORS AND USES THEREOF ALTOS LABS, INC. 2024-04-18 — — US disclosed
US-20230301970-A1 CARBOXAMIDE DERIVATIVES NOVARTIS PHARMACEUTICALS UK LIMITED (GB) 2023-09-28 — — US disclosed
US-8211927-B2 5-phenyl-isoxazole-3-carboxamide derivatives as TRPV1 modulators MSD, Oss B.V. (NL) 2012-07-03 — — US disclosed
US-20120071481-A1 ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES MERCK SHARP & DOHME B.V. (NL) 2012-03-22 — — US disclosed
EP-2185530-B1 5-PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS ORGANON NV (NL) 2011-09-14 — — EP disclosed
US-20110065764-A1 5- PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS N.V. Organon and Pharmacopeia, LLC (NL) 2011-03-17 — — US disclosed
EP-2185530-A1 5-PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS N.V. Organon (NL) 2010-05-19 — — EP disclosed
WO-2009016241-A1 5-PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS N.V. ORGANON (NL) 2009-02-05 — — WO disclosed
US-20070054902-A1 Isoxazole derivatives as peroxisome proliferator-activated receptors agonists SHIONOGI & CO., LTD. (JP) 2007-03-08 — — US disclosed
US-20070054902-A1 Isoxazole derivatives as peroxisome proliferator-activated receptors agonists SHIONOGI & CO., LTD. (JP) 2007-03-08 — — US disclosed
US-20070054902-A1 Isoxazole derivatives as peroxisome proliferator-activated receptors agonists SHIONOGI & CO., LTD. (JP) 2007-03-08 — — US disclosed
EP-1690538-A1 ISOXAZOLE DERIVATIVE HAVING AGONISTIC ACTIVITY AGAINST PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR SHIONOGI & CO., LTD. (JP) 2006-08-16 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124434-A1 ATF6 INHIBITORS AND USES THEREOF ATF4, XBP1, ATF1 TARBP2 1252/4885ALDH1A1 4447/4885KDM4E 4305/4885
US-12325702-B2 ATF6 inhibitors and uses thereof ATF4, XBP1, ATF1 TARBP2 1252/4885ALDH1A1 4447/4885KDM4E 4305/4885
US-20230301970-A1 CARBOXAMIDE DERIVATIVES SIRT1, ADCY5, ASIC1 TARBP2 4013/4885ALDH1A1 183/4885KDM4E 703/4885
US-20110065764-A1 5- PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS TRPV1, TRPV5, TRPV3 TARBP2 3404/4885ALDH1A1 1212/4885KDM4E 2329/4885
US-20250179061-A1 RIP1 MODULATORS, PREPARATIONS, AND USES THEREOF RIPK1, RIPK2, RIPK3 TARBP2 1681/4885ALDH1A1 4611/4885KDM4E 3746/4885
US-20070054902-A1 Isoxazole derivatives as peroxisome proliferator-activated receptors agonists NR1H3, NR1H2, RXRA TARBP2 3815/4885ALDH1A1 1698/4885KDM4E 3202/4885
US-20120071481-A1 ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES TRPV1, TRPV5, TRPV3 TARBP2 3588/4885ALDH1A1 865/4885KDM4E 2535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.