Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470705 | 0.86 | MAPK14 (0.38) | MAPK1VNN1MAP2K4KDM4EADCY1 | |
| SCHEMBL7473487 | 0.84 | VNN1 (0.49) | VNN1MAP2K4KDM4EADCY1 | |
| SCHEMBL7478461 | 0.82 | HTT (0.44) | VNN1 | |
| SCHEMBL7476789 | 0.81 | FABP4 (0.44) | MAPK1VNN1 | |
| SCHEMBL7469535 | 0.79 | MAPK14 (0.40) | MAPK1VNN1MAP2K4 | |
| SCHEMBL7471940 | 0.78 | VNN1 (0.39) | VNN1MAP2K4 | |
| SCHEMBL7480868 | 0.78 | NPY5R (0.41) | MAPK1MAP2K4KDM4E | |
| SCHEMBL7476723 | 0.78 | PARP1 (0.40) | MAPK1MAP2K4 | |
| SCHEMBL5762375 | 0.78 | PBRM1 (0.44) | MAPK1MAP2K4KDM4E | |
| SCHEMBL7473920 | 0.77 | KDM4E (0.40) | MAPK1MAP2K4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218346-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021591-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-29 | — | — | WO | disclosed |
| EP-1075467-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999057101-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-11 | — | — | WO | disclosed |