Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 5/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.36 |
| ▸ | HAO2 | Q9NYQ3 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5762375 | 0.88 | PBRM1 (0.44) | GAAMAP2K4MAPK1MAPK6ALDH1A1 | |
| SCHEMBL7472841 | 0.86 | HSD17B14 (0.44) | MAP2K4MAPK1MAPK6HSD17B14 | |
| SCHEMBL7474871 | 0.85 | MAP2K4 (0.39) | MAP2K4MAPK1MAPK6ALDH1A1SMN1; SMN2 | |
| SCHEMBL7476723 | 0.85 | PARP1 (0.40) | GAAMAP2K4MAPK1MAPK6KMT2A | |
| SCHEMBL7469135 | 0.85 | PTPN1 (0.41) | MAP2K4MAPK1MAPK6ALDH1A1SMN1; SMN2 | |
| SCHEMBL7473487 | 0.85 | VNN1 (0.49) | GAAMAP2K4KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL7476607 | 0.83 | MAPK1 (0.38) | MAP2K4MAPK1MAPK6ALDH1A1SMN1; SMN2 | |
| SCHEMBL7473920 | 0.82 | KDM4E (0.40) | MAP2K4MAPK1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7477623 | 0.82 | MAP2K4 (0.49) | MAP2K4MAOBMAP2K7 | |
| SCHEMBL7483107 | 0.81 | MAPT (0.47) | GAAKMT2AALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218346-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021591-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-29 | — | — | WO | disclosed |
| EP-1075467-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999057101-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-11 | — | — | WO | disclosed |