Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
| ▸ | IKBKB | O14920 | 3/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 2/20 | 0.51 |
| ▸ | CCND1 | P24385 | 2/20 | 0.51 |
| ▸ | CCND2 | P30279 | 2/20 | 0.51 |
| ▸ | CCND3 | P30281 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | AGER | Q15109 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8547700 | 0.99 | JAK2 (0.58) | JAK2JAK3IKBKBABL1BCR | |
| SCHEMBL7476936 | 0.88 | IKBKB (0.72) | JAK2JAK3IKBKBABL1BCR | |
| SCHEMBL7474933 | 0.88 | ABL1 (0.68) | JAK2JAK3IKBKBABL1BCR | |
| SCHEMBL7466120 | 0.87 | AGER (0.67) | JAK2JAK3ABL1BCRPIK3CA | |
| SCHEMBL7471337 | 0.85 | IKBKB (0.64) | JAK2JAK3IKBKBABL1BCR | |
| SCHEMBL13605335 | 0.82 | BMP4 (0.54) | CDK4CCND1CCND2CCND3BRAF | |
| SCHEMBL6362601 | 0.80 | CDK2 (0.62) | CDK4 | |
| SCHEMBL7465398 | 0.79 | PIK3CG (0.76) | IKBKBCDK4CCND1PIK3CAPIK3CB | |
| SCHEMBL3247819 | 0.77 | RIPK2 (0.51) | JAK2JAK3IKBKBABL1BCR | |
| SCHEMBL7464616 | 0.77 | ABL1 (0.68) | ABL1BCRPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | claimed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | claimed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | claimed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | claimed |
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0549880-B1 | N-(3-(2-(1H-imidazol-1-yl)ethoxy)phenyl)-4-(2-thienyl)-2-pyrimidinamine and pharmacologically acceptable salts | AMERICAN CYANAMID CO (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| EP-0549880-A1 | N-(3-(2-(1H-imidazol-1-yl)ethoxy)phenyl)-4-(2-thienyl)-2-pyrimidinamine and pharmacologically acceptable salts | AMERICAN CYANAMID COMPANY (US) | 1993-07-07 | — | — | EP | disclosed |
| US-5162328-A | Antiasthma agents, antiallergens | AMERICAN CYANAMID COMPANY (US) | 1992-11-10 | — | — | US | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | disclosed |