Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473162 | 0.89 | F10 (0.43) | SMN1; SMN2F2F10MCHR1PRSS1 | |
| Hydrochloric Acid SCHEMBL8561724 | 0.88 | F10 (0.43) | SMN1; SMN2F2F10MCHR1PRSS1 | |
| SCHEMBL8562703 | 0.87 | F2 (0.35) | F2F10KHKSLC6A2USP30 | |
| SCHEMBL8562707 | 0.87 | F2 (0.35) | F2F10KHKSLC6A2USP30 | |
| Hydrochloric Acid SCHEMBL8561453 | 0.87 | F2 (0.35) | F2F10KHKSLC6A2USP30 | |
| SCHEMBL7474111 | 0.83 | PARP1 (0.38) | F2F10PARP1HRH3DRD2 | |
| SCHEMBL7474107 | 0.83 | PARP1 (0.38) | F2F10PARP1HRH3DRD2 | |
| Hydrochloric Acid SCHEMBL7476507 | 0.83 | KHK (0.36) | F2F10PRSS1ALDH1A1KHK | |
| SCHEMBL7468477 | 0.82 | DRD2 (0.35) | F2F10MCHR1HRH1HRH3 | |
| SCHEMBL7468482 | 0.82 | DRD2 (0.35) | F2F10MCHR1HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777667-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | Dr. Karl Thomae GmbH (DE) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996005194-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | DR. KARL THOMAE GMBH (DE) | 1996-02-22 | — | — | WO | disclosed |