Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT known ✓ | P43490 | 2/20 | 0.34 |
| ▸ | HRAS | P01112 | 9/20 | 0.42 |
| ▸ | ESR1 | P03372 | 9/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.42 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470540 | 0.89 | MEN1 (0.45) | HRASESR1ESR2MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL7468841 | 0.88 | MEN1 (0.44) | HRASESR1ESR2MAPTMEN1 | |
| SCHEMBL7472023 | 0.86 | HRAS (0.51) | HRASESR1ESR2EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL7466261 | 0.84 | HRAS (0.49) | HRASESR1ESR2EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL7471999 | 0.83 | HRAS (0.52) | HRASESR1ESR2EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL7477283 | 0.81 | HRAS (0.50) | HRASESR1ESR2EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL7475008 | 0.80 | HRAS (0.64) | HRASESR1ESR2EGFRERBB2 | |
| SCHEMBL7469237 | 0.80 | HRAS (0.45) | HRASESR1ESR2EGFRERBB2 | |
| SCHEMBL7467474 | 0.80 | HRAS (0.47) | HRASESR1ESR2EGFRERBB2 | |
| SCHEMBL8298671 | 0.78 | HRAS (0.46) | HRASESR1ESR2EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711768-B1 | BENZIMIDAZOLE DERIVATIVE | MITSUI CHEMICALS INC (JP) | 2002-02-13 | — | — | EP | disclosed |